Vicodin vs Oxycodone for pain is the most popular use we know of; both drugs belong to a class of pain relievers that may have side effects. However, it differs from person to person. Thus, cannot be dismissed for their effectiveness.
Vicodin is mainly known for its dual action as a pain reliever and antipyretic. In contrast, Oxycodone is known for its pain-relieving properties. Both drugs are used for managing pain across the spectrum. However, one is better than the other; we’ll find out which in the following article.
The following sections will also explore how the two differ and compete in their efficacy for pain relief. So, read on to learn all about the dosage and use cases.
Vicodin vs Oxycodone: How Do They Compare?
Vicodin vs oxycodone potency can only be compared after you know their respective composition. So, here’s looking:
Vicodin – Composition & How it Works
Vicodin is currently discontinued in the U.S., but generic versions are available. If your physician prescribes the drug, they will do so under a different, available brand name.
Vicodin is the (discontinued) brand name that contains a combination of acetaminophen and hydrocodone. Hydrocodone is an opioid pain medication that helps relieve pain by changing the brain and nervous system’s response to pain.
Acetaminophen, on the other hand, acts as both a pain reliever and an antipyretic or fever reducer. It is a member of the NSAID drug class and shows significant effects on moderate to severe pain and fever.
Moreover, the drug provides relief from pain by acting on the receptors in the central nervous system. Its binding to the mu-opioid receptors in the CNS inhibits (stops) the ascending pathways, decreasing perception and response to pain.
Thus, Vicodin acts as a CNS depressant.
Oxycodone – Composition & How it Works
An opioid used for pain management; Oxycodone is an opioid medication that treats moderate to severe pain. The drug is semi-synthetically made and is currently available in the immediate release form to treat moderate to severe pain.
The extended-release formulation is available for chronic moderate to severe pain, which requires opioid analgesics for a prolonged time. The drug works by selectively binding to the CNS’s mu-, kappa- and delta-opioid receptors.
The activation of the mu-opioid receptor triggers a G protein-coupled receptor signaling pathway. This inhibits the N-type voltage-operated calcium channels, thereby stopping the pain.
Now, let’s look at the differences between the two drugs.
Vicodin vs Oxycodone Differences
Here’s a look at the major Vicodin vs. oxycodone differences, which also affect their action on pain:
| Factor | Vicodin | Oxycodone |
| Composition | Vicodin is a combination of hydrocodone and acetaminophen | It is a single opioid medication |
| Potency | Less potent in comparison, larger dose of Vicodin will help achieve the same levels as a small dose of oxycodone | 1.5 times more potent than Vicodin. |
| Effects/Action | Relieves pain and reduces fever | Helps alleviate pain in moderate to severe cases. |
| Efficacy | Effective at managing moderate to severe pain and reducing fever for short term. | It is more effective than Vicodin at managing severe pain for a longer time. |
Vicodin vs Oxycodone Side Effects
Both Vicodin and Oxycodone have the potential to cause mild to severe side effects. This is due to their potency, which may not be suitable for people, especially if they have an underlying condition for which the drug is contraindicated.
| These side effects may be due to the dosage, misuse, or mixing of the drugs with another medication. Always inform your physician about all the medications that you are consuming before starting either Vicodin or Oxycodone. |
Here’s a look at their different Vicodin vs oxycodone side effects:
Common side effects of Vicodin vs Oxycodone include:
- Nausea and vomiting
- Drowsiness
- Constipation
- Headache
- Lightheadedness
- Dizziness
- Sedation
Some of the more severe side effects of consuming either drug include:
- Heart failure
- Respiratory depression is evident through shallow breathing, noisy breathing, or sleep-related breathing issues.
- Seizures
- Overdose due to too much exposure at one time
Other side effects include:
- Vicodin can cause tiredness, upper abdominal pain, and loss of appetite
- Oxycodone can cause increased anxiety, dry mouth, abuse and tolerance
So, call your healthcare provider or local physician immediately if you experience any of the side effects listed here.
Vicodin Vs Oxycodone Dosage
The Vicodin vs oxycodone dosage depends on the following factors:
- condition
- age
- The cause of your pain
- Presence of a serious illness such as lung, heart, kidney or liver disease
- Other medications you take
- Risk for abuse or addiction (history of alcohol or drug abuse)
All these factors play a crucial role in determining the dosage your physician will prescribe for your condition. The further increase or decrease in dosage depends on your tolerance and any side effects you experience.
The dosage is usually low for a patient who has never been prescribed the drug before. Oxycodone’s dosage may range between 5-80 mg, but the latter is only for severe cases such as chronic arthritis pain.
Considerations Before Starting Your Prescription
Both Vicodin vs Oxycodone are habit-forming, take them strictly as directed. Do not take more off the drugs. Take them often or in a different way than the doctor prescribed. Inform your doctor if you or anyone in your family has a history of drug or alcohol abuse.
If anyone in your family has a history of overusing prescription medication or had an overdose, inform your physician immediately. In addition, if you think you are developing an opioid habit, immediately talk to your doctor and ask for guidance.
Do not chew, crush, dissolve, or pre-soak either of the two drugs – especially the extended-release forms – before consuming. Moreover, it can lead to the quick release of higher doses of the drug, leading to overdose and even death in some cases.
Call the following helpline for further support:
U.S. Substance Abuse and Mental Health Services Administration (SAMHSA) National Helpline at 1-800-662-HELP.
Wrapping It Up!
That was all about the way Vicodin vs Oxycodone can differ despite being from the same drug class. The article helps you understand the difference between the two drugs and how to take them.
Moreover, there are several side effects of the two drugs; however, they depend on the dosage and use, among many other factors illustrated above. So, the article also tells you how to avoid these side effects through Considerations at the end.
Never self-medicate for any condition, especially pain, as effective drugs such as opioids have habit-forming tendencies.
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